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Article

Modelling cardiac fibrosis using three-dimensional cardiac microtissues derived from human embryonic stem cells

13 Feb 2019

Abstract excerpt

BACKGROUND: Cardiac fibrosis is the most common pathway of many cardiac diseases. To date, there has been no suitable in vitro cardiac fibrosis model that could sufficiently mimic the complex environment of the human heart. Here, a three-dimensional (3D) cardiac sphere platform of contractile cardiac microtissue, composed of human embryonic stem cell (hESC)-derived cardiomyocytes (CMs) and mesenchymal stem cells...

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PMID: 30809271
DOI: 10.1186/s13036-019-0139-6

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