Article

Tyrosine Inhibits TyrRS-mediated DNA Repair and Induces Neuronal Oxidative DNA Damage

2021-08-13

Abstract excerpt

<title>Abstract</title> <p>Human aging and neurodegenerative diseases accumulate oxidative DNA damage-associated mutations in neurons. Circadian-regulated tyrosine (Tyr) is increased during aging and in Alzheimer’s Disease (AD). Tyr exacerbates the cognitive decline in the elderly and AD patients. Tyrosyl-tRNA synthetase (TyrRS) that activates Tyr for protein synthesis and participates in DNA repair is depleted i...

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Literature Corpus work: caddb3c6-4718-5d1e-8184-83971373bf47
DOI: 10.21203/rs.3.rs-785404/v1

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