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Article

Senescence and impaired DNA damage responses in alpha-synucleinopathy models

1 Feb 2022

Abstract excerpt

α-Synuclein is a crucial element in the pathogenesis of Parkinson's disease (PD) and related neurological diseases. Although numerous studies have presented potential mechanisms underlying its pathogenesis, the understanding of α-synuclein-mediated neurodegeneration remains far from complete. Here, we show that overexpression of α-synuclein leads to impaired DNA repair and cellular senescence. Transcriptome...

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PMID: 35136202
DOI: 10.1038/s12276-022-00727-x

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