Article

Targeted intervention of senescence induced by a 5′ half fragment of tRNA <sup>Seca(NCA)</sup> with antisense oligonucleotide extends healthspan and lifespan in mice

2025-03-26

Abstract excerpt

In light of increasing attention being paid to aging research globally, the accumulation of aging hallmarks and their corresponding targeting therapeutics have been substantially revealed. However, uncovering the genuine drivers within epigenetic alterations that lead to aging remains a formidable challenge. In this study, we identified tRNA Sec(NCA) as the most severely damaged tRNA species in the kidneys of nat...

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Literature Corpus work: ec4e45a5-1561-596a-8efa-91477f5a05af
DOI: 10.1101/2025.03.24.644848

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Targeted intervention of senescence induced by a 5′ half fragment of tRNA <sup>Seca(NCA)</sup> with antisense oligonucleotide extends healthspan and lifespan in miceDOI 10.1101/2025.03.24.644848Read

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