Article
Separation of coiled-coil structures in lamin A/C is required for elongation of the filament
2020-09-29
Abstract excerpt
Intermediate filaments (IFs) commonly have structural elements of a central α-helical coiled-coil domain consisting of coil 1a, coil 1b, coil 2, and their flanking linkers. Recently, crystal structure of a long lamin A/C fragment was determined and showed detailed features of a tetrameric unit. The structure further suggested a new binding mode between tetramers, designated eA22, where a parallel overlap of coil 1...
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Identifiers and source
- Literature Corpus work
- cadd349d-8eab-52be-acc9-8bab413135cf
- DOI
- 10.1101/2020.09.29.317933