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Article

Separation of Coiled-Coil Structures in Lamin A/C Is Required for the Elongation of the Filament.

Cells - 31 Dec 2020

Ahn Jinsook, Jeong Soyeon, Kang So-Mi, Jo Inseong, Park Bum-Joon, Ha Nam-Chul

Abstract excerpt

Intermediate filaments (IFs) commonly have structural elements of a central α-helical coiled-coil domain consisting of coil 1a, coil 1b, coil 2, and their flanking linkers. Recently, the crystal structure of a long lamin A/C fragment was determined and showed detailed features of a tetrameric unit. The structure further suggested a new binding mode between tetramers, designated eA22, where a parallel overlap of...

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Identifiers

PMID: 33396475
DOI: 10.3390/cells10010055
PMCID: PMC7824274

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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