Article
Atomic structure of the vimentin central α-helical domain and its implications for intermediate filament assembly.
Proceedings of the National Academy of Sciences of the United States of America - 21 Aug 2012
Chernyatina Anastasia A, Nicolet Stefan, Aebi Ueli, Herrmann Harald, Strelkov Sergei V
Abstract excerpt
Together with actin filaments and microtubules, intermediate filaments (IFs) are the basic cytoskeletal components of metazoan cells. Over 80 human diseases have been linked to mutations in various IF proteins to date. However, the filament structure is far from being resolved at the atomic level, which hampers rational understanding of IF pathologies. The elementary building block of all IF proteins is a dimer...
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