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Targeted chromosomal barcoding establishes direct genotype-phenotype associations for antibiotic resistance in <i>Mycobacterium abscessus</i>

2022-12-05

Abstract excerpt

<h4>ABSTRACT</h4> A bedaquiline resistant Mycobacterium abscessus isolate was sequenced and a candidate mutation in the atpE gene was identified as responsible for the antibiotic resistance phenotype. To establish a direct genotype-phenotype relationship of this D29A mutation, we developed a recombineering-based method consisting of the specific replacement of the desired mutation in the bacterial chromosome. A...

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Literature Corpus work
cac64315-d8bd-53d6-befd-42afe23af095
DOI
10.1101/2022.12.01.518803
Open publication

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