Article

The level of oncogenic Ras controls the malignant transformation of Lkb1 mutant tissue in vivo

2020-09-25

Abstract excerpt

The genetic and metabolic heterogeneity of RAS-driven cancers has confounded therapeutic strategies in the clinic. To address this, rapid and genetically tractable animal models are needed that recapitulate the heterogeneity of RAS-driven cancers in vivo. Here, we generate a Drosophila melanogaster model of Ras/Lkb1mutant carcinoma. We show that low-level expression of oncogenic Ras (Ras Lo ) promotes the surviv...

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Literature Corpus work: caa03f80-f281-5ccb-b921-0a86e5f87cf2
DOI: 10.1101/2020.09.25.308080

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