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Article

The level of oncogenic Ras determines the malignant transformation of Lkb1 mutant tissue in vivo.

Communications biology - 29 Jan 2021

Rackley Briana, Seong Chang-Soo, Kiely Evan, Parker Rebecca E, Rupji Manali, Dwivedi Bhakti, Heddleston John M, Giang William, Anthony Neil, Chew Teng-Leong, Gilbert-Ross Melissa

Abstract excerpt

The genetic and metabolic heterogeneity of RAS-driven cancers has confounded therapeutic strategies in the clinic. To address this, rapid and genetically tractable animal models are needed that recapitulate the heterogeneity of RAS-driven cancers in vivo. Here, we generate a Drosophila melanogaster model of Ras/Lkb1 mutant carcinoma. We show that low-level expression of oncogenic Ras (RasLow) promotes the...

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Identifiers

PMID: 33514834
DOI: 10.1038/s42003-021-01663-8
PMCID: PMC7846793

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