Article
Multi-omics study reveals different pathogenesis of the generation of skin lesions in SLE and IDLE patients.
Journal of autoimmunity - 1 Jun 2024
Li Qianwen, Jia Chen, Pan Wenjing, Liu Hongmei, Tang Congli, Weber Daniel, Chen Kaili, Long Hai, Byrne-Steele Miranda L, Han Jian, He Nongyue, Xiao Rong, Zhao Ming, Che Nan, Guo Qing, Gui Guangji, Li Shanshan, Si Henan, Guo Shuping, Liu Hongye, Wang Gang, Zhu Guannan, Yang Bin, Wang Yu, Ding Yan, Yang Xianxu, Akihiko Yoshimura, Lu Liwei, Chang Christopher, Chan Vera, Lau Chak-Sing, Qi Hai, Liu Wanli, Li Song, Wu Haijing, Lu Qianjin
Abstract excerpt
Lupus erythematosus (LE) is a heterogeneous, antibody-mediated autoimmune disease. Isolate discoid LE (IDLE) and systematic LE (SLE) are traditionally regarded as the two ends of the spectrum, ranging from skin-limited damage to life-threatening multi-organ involvement. Both belong to LE, but IDLE and SLE differ in appearance of skin lesions, autoantibody panels, pathological changes, treatments, and...
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