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Article

Proteolytic processing of CXCL11 by CD13/aminopeptidase N impairs CXCR3 and CXCR7 binding and signaling and reduces lymphocyte and endothelial cell migration.

Blood - 1 Jul 2007

Proost Paul, Mortier Anneleen, Loos Tamara, Vandercappellen Jo, Gouwy Mieke, Ronsse Isabelle, Schutyser Evemie, Put Willy, Parmentier Marc, Struyf Sofie, Van Damme Jo

Abstract excerpt

CXCR3 ligands were secreted by tissue fibroblasts and peripheral blood-derived mononuclear leukocytes in response to interferon-gamma (IFN-gamma) and Toll-like receptor (TLR) ligands. Subsequent purification and identification revealed the presence of truncated CXCL11 variants missing up to 6 amino acids. In combination with CD26/dipeptidyl peptidase IV, the metalloprotease aminopeptidase N (APN), identical to...

Read the complete abstract on PubMed

Topics

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Share to CD13 Antigens
Share to Chemokines, CXC

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endothelial Cells

Share to Lymphocytes

Share to Lymphocytes, Tumor-Infiltrating

Share to Receptors, Chemokine

Share to Receptors, CXCR3

Share to Receptors, G-Protein-Coupled

Source

Identifiers

PMID: 17363734
DOI: 10.1182/blood-2006-10-049072

Genes

CXCL11
CXCR3
CXCL8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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