Article
Evolution of multidrug resistance during Staphylococcus aureus infection involves mutation of the essential two component regulator WalKR.
PLoS pathogens - 1 Nov 2011
Howden Benjamin P, McEvoy Christopher R E, Allen David L, Chua Kyra, Gao Wei, Harrison Paul F, Bell Jan, Coombs Geoffrey, Bennett-Wood Vicki, Porter Jessica L, Robins-Browne Roy, Davies John K, Seemann Torsten, Stinear Timothy P
Abstract excerpt
Antimicrobial resistance in Staphylococcus aureus is a major public health threat, compounded by emergence of strains with resistance to vancomycin and daptomycin, both last line antimicrobials. Here we have performed high throughput DNA sequencing and comparative genomics for five clinical pairs of vancomycin-susceptible (VSSA) and vancomycin-intermediate ST239 S. aureus (VISA); each pair isolated before and...
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