Article

IL-17A Alters Human Cortical Development in a 3D Ex Vivo Model of Maternal Immune Activation

2024-10-31

Abstract excerpt

Human brain development depends on the coordinated interaction of diverse cell types and extracellular matrix (ECM) components, which are essential for proper neurogenesis and cortical organization. Epidemiological and animal studies have demonstrated that maternal immune activation (MIA) disrupts brain development, leading to impaired neurogenesis and increased risk of neurodevelopmental disorders (NDDs), includi...

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Literature Corpus work: ca3b541a-bdcc-5f1b-b4d0-336e317b031f
DOI: 10.1101/2024.10.30.621011

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