Article

Dual Transcriptomic and Epigenomic Signatures of THC Exposure in Human Prefrontal Cortex Development

2026-01-08

Abstract excerpt

Prenatal cannabis use is increasing globally, with estimates up to 35% in North America. Fetal exposure to Δ9-tetrahydrocannabinol (THC) has been linked to neurodevelopmental deficits. Yet mechanistic understanding remains limited because animal models incompletely recapitulate human fetal development, and human-relevant in vitro platforms are scarce. To address this gap, we generated human iPSC-derived prefrontal...

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Literature Corpus work: 9ed227cc-06f6-5e7c-9f72-8fa8e6cabb99
DOI: 10.64898/2026.01.08.698442

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