Article

Deciphering Cell-Type and Temporal-Specific Matrisome Expression Signatures in Human Cortical Development and Neurodevelopmental Disorders via scRNA-Seq Meta-Analysis

2025-02-25

Abstract excerpt

Human cortical development is a complex process involving the proliferation, differentiation, and migration of progenitor cells, all coordinated within a dynamic extracellular matrix (ECM). ECM plays a crucial role in guiding these processes, yet its specific contributions and the implications of its dysregulation in neurodevelopmental disorders (NDDs) remain underexplored. In this study, we conducted a meta-analy...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c745ba93-153f-551e-a170-447e607a8da6
DOI: 10.1101/2025.02.24.639826

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Deciphering Cell-Type and Temporal-Specific Matrisome Expression Signatures in Human Cortical Development and Neurodevelopmental Disorders via scRNA-Seq Meta-AnalysisDOI 10.1101/2025.02.24.639826Read

A single cell transcriptomic analysis of human neocortical developmentSemantic proximity Read

Developmental isoform diversity in the human neocortex informs neuropsychiatric risk mechanismsSemantic proximity Read

An integrative single-cell atlas to explore the cellular and temporal specificity of neurological disorder genes during human brain developmentSemantic proximity Read

A consensus atlas of human brain development defines cell type-specific maturation trajectories across the lifespanSemantic proximity Read

Unlocking disease associations during prefrontal cortex development with scRNAseqSemantic proximity Read

Single-cell transcriptomic catalog of mouse cortical developmentSemantic proximity Read

A Curated Compendium of Transcriptomic Data for the Exploration of Neocortical DevelopmentSemantic proximity Read

Comprehensive cell atlas of the first-trimester developing human brainSemantic proximity Read

Developmental isoform diversity in the human neocortex informs neuropsychiatric risk mechanisms.Semantic proximity Read

Developmental landscape of human forebrain at a single-cell level unveils early waves of oligodendrogenesisSemantic proximity Read

NeuRoDev resolves lifelong temporal and cellular variation in human cortical gene expressionSemantic proximity Read

A Meta-Atlas of the Developing Human Cortex Identifies Modules Driving Cell Subtype SpecificationSemantic proximity Read