Article

Maternal immune activation imprints postnatal Treg insufficiency driving meningeal neuroinflammation and reversible autistic behaviors in mice and humans

2026-06-16

Abstract excerpt

<title>Abstract</title> <p> Maternal immune activation (MIA) during pregnancy induces autism spectrum disorder (ASD)-like phenotypes in offspring. While maternal IL-17 signaling has been implicated in prenatal brain alterations, the postnatal mechanisms sustaining this phenotype remain unknown. Here, we show that MIA in mice imprints a persistent postnatal insufficiency of regulatory T cells (Tregs) in offspring...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fdab7639-3d26-5ab0-ac5c-d47f182b860b
DOI: 10.21203/rs.3.rs-9968974/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Maternal immune activation imprints postnatal Treg insufficiency driving meningeal neuroinflammation and reversible autistic behaviors in mice and humansDOI 10.21203/rs.3.rs-9968974/v1Read

Maternal immune activation imprints a regulatory T cell deficiency in offspring that drives an autism-like phenotypeSemantic proximity Read

At the crux of maternal immune activation: Viruses, microglia, microbes, and <scp>IL‐17A</scp>Semantic proximity Read

The role of maternal immune activation in immunological and neurological pathogenesis of autismSemantic proximity Read

The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring.Semantic proximity Read

Maternal immune activation dysregulation of the fetal brain transcriptome and relevance to the pathophysiology of autism spectrum disorderSemantic proximity Read

Maternal immune activation: Implications for neuropsychiatric disordersSemantic proximity Read

Abnormal neutrophil-to-lymphocyte ratio in children with autism spectrum disorder and history of maternal immune activationSemantic proximity Read

Maternal immune activation dysregulation of the fetal brain transcriptome and relevance to the pathophysiology of autism spectrum disorderSemantic proximity Read

Maternal immune activation as an epidemiological risk factor for neurodevelopmental disorders: Considerations of timing, severity, individual differences, and sex in human and rodent studiesSemantic proximity Read

Microglia from offspring of dams with allergic asthma exhibit epigenomic alterations in genes dysregulated in autismSemantic proximity Read

Maternal immune activation, central nervous system development and behavioral phenotypesSemantic proximity Read

Microenvironment dysregulation in autism spectrum disorder: Immune, epigenetic, synaptic, and gut-brain mechanisms.Semantic proximity Read