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Article

Stochastic Fluctuations Drive Non-genetic Evolution of Proliferation in Clonal Cancer Cell Populations.

Bulletin of mathematical biology - 23 Dec 2022

Ortega-Sabater Carmen, F Calvo Gabriel, Dinić Jelena, Podolski Ana, Pesic Milica, Pérez-García Víctor

Abstract excerpt

Evolutionary dynamics allows us to understand many changes happening in a broad variety of biological systems, ranging from individuals to complete ecosystems. It is also behind a number of remarkable organizational changes that happen during the natural history of cancers. These reflect tumour heterogeneity, which is present at all cellular levels, including the genome, proteome and phenome, shaping its...

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PMID: 36562835
DOI: 10.1007/s11538-022-01113-4

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