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Article

Joint analysis of mutational and transcriptional landscapes in human cancer reveals key perturbations during cancer evolution.

Genome biology - 8 Mar 2024

Cho Jae-Won, Cao Jingyi, Hemberg Martin

Abstract excerpt

BACKGROUND: Tumors are able to acquire new capabilities, including traits such as drug resistance and metastasis that are associated with unfavorable clinical outcomes. Single-cell technologies have made it possible to study both mutational and transcriptomic profiles, but as most studies have been conducted on model systems, little is known about cancer evolution in human patients. Hence, a better understanding...

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Identifiers

PMID: 38459554
DOI: 10.1186/s13059-024-03201-1
PMCID: PMC10921788

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