Article
Clonal evolution in cancer.
Nature - 18 Jan 2012
Greaves Mel, Maley Carlo C
Abstract excerpt
Cancers evolve by a reiterative process of clonal expansion, genetic diversification and clonal selection within the adaptive landscapes of tissue ecosystems. The dynamics are complex, with highly variable patterns of genetic diversity and resulting clonal architecture. Therapeutic intervention may destroy cancer clones and erode their habitats, but it can also inadvertently provide a potent selective pressure...
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