Article

NK2R signaling governs intestinal lipid mobilization and mucosal inflammation

2025-11-23

Abstract excerpt

<h4>ABSTRACT</h4> Neuropeptidergic control of lipid metabolism is conserved and increasingly implicated in metabolic diseases, but receptor-level mechanisms remain unclear. Here we identify the neurokinin-2 receptor (NK2R) as a central node linking tachykinin signals to intestinal lipid mobilization, epithelial composition, and mucosal inflammation. Across complementary genetic and pharmacological perturbations,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c9dd74e3-4278-52f3-a46e-d4239b109a8f
DOI: 10.1101/2025.11.21.689675

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

NK2R signaling governs intestinal lipid mobilization and mucosal inflammationDOI 10.1101/2025.11.21.689675Read

CXCR3+ LEF1low NK cells cause immunopathological hepatic damage in MASHSemantic proximity Read

A tachykinin-like neuroendocrine signalling axis couples central serotonin action and nutrient sensing with peripheral lipid metabolism.Semantic proximity Read

Nuclear factor interleukin 3 and metabolic dysfunction-associated fatty liver disease developmentSemantic proximity Read

Pleiotropic effects of prokineticin 2 in the control of energy metabolism.Semantic proximity Read

The <i>Drosophila</i> G protein-coupled receptor, GulpR, is essential for lipid mobilization in response to nutrient-limitationSemantic proximity Read

Acyloxyacyl Hydrolase Modulates the Gut Microbiome Through Transcriptional Regulators of Corticotropin-Releasing FactorSemantic proximity Read

Role of Janus Kinase 3 in Predisposition to Obesity-associated Metabolic Syndrome.Semantic proximity Read

The PPARα Regulation of the Gut Physiology in Regard to Interaction with Microbiota, Intestinal Immunity, Metabolism, and PermeabilitySemantic proximity Read

Role of Natural Killer T Cells in the Development of Obesity and Insulin Resistance: Insights From Recent ProgressSemantic proximity Read

Antagonizing the metabolic hormone cholecystokinin (CCK) and its receptor CCKAR in the lung abolishes obesity-induced airway hyperresponsivenessSemantic proximity Read

Gpr37 modulates the severity of inflammation-induced GI dysmotility by regulating enteric reactive gliosisSemantic proximity Read

SR9009 regulates macrophage polarization via the NR1D1/NF-κB axis to ameliorate obesity-associated ulcerative colitisSemantic proximity Read