Article

Antagonizing the metabolic hormone cholecystokinin (CCK) and its receptor CCKAR in the lung abolishes obesity-induced airway hyperresponsiveness

2021-09-08

Abstract excerpt

<title>Abstract</title> <p>Obesity is a significant co-morbidity that associates with increased prevalence and severity of asthma. The mechanism underlying the obesity-asthma association remains poorly understood, and for obese asthmatics there is no effective therapy for obese asthmatics. Here we show that cholecystokinin (CCK)—a metabolic hormone best known for its roles in satiety regulation and fat metabolism...

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Literature Corpus work: 4e72355d-55c1-526b-a7ba-78169dd3daf6
DOI: 10.21203/rs.3.rs-841619/v1

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