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Engineering a novel probiotic toolkit in <i>Escherichia coli Nissle1917</i> for sensing and mitigating gut inflammatory diseases

2024-06-17

Abstract excerpt

Inflammatory Bowel Disease (IBD) is characterized by chronic intestinal inflammation with no cure and limited treatment options that often have systemic side effects. In this study, we developed a target-specific system to potentially treat IBD by engineering the probiotic bacterium Escherichia coli Nissle 1917 (EcN). Our modular system comprises three components: a transcription factor-based sensor (NorR) capabl...

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Identifiers and source

Literature Corpus work
c9ce051b-994a-54b1-8a06-c5a67cba4d8c
DOI
10.1101/2024.06.17.599326
Open publication

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Engineering a novel probiotic toolkit in <i>Escherichia coli Nissle1917</i> for sensing and mitigating gut inflammatory diseasesDOI 10.1101/2024.06.17.599326
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