Article

Modulating Innate Immune Responses to Curli Fibers Through Protein Engineering

2026-03-25

Abstract excerpt

<h4>ABSTRACT</h4> Curli fibers produced by Escherichia coli are functional amyloids that activate Toll-like receptor 2 (TLR2), initiating innate immune responses at mucosal surfaces. While microbiome-derived curli contribute to host-microbe interactions, their intrinsic immunostimulatory activity limits their utility as programmable scaffolds for engineered probiotic systems, and dysregulated TLR2 activation has...

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Identifiers and source

Literature Corpus work: 5bd94a85-a8c1-5621-ab2f-847deb774b1c
DOI: 10.64898/2026.03.23.713613

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