Article
A mitochondrial protein compendium elucidates complex I disease biology.
Cell - 11 Jul 2008
Pagliarini David J, Calvo Sarah E, Chang Betty, Sheth Sunil A, Vafai Scott B, Ong Shao-En, Walford Geoffrey A, Sugiana Canny, Boneh Avihu, Chen William K, Hill David E, Vidal Marc, Evans James G, Thorburn David R, Carr Steven A, Mootha Vamsi K
Abstract excerpt
Mitochondria are complex organelles whose dysfunction underlies a broad spectrum of human diseases. Identifying all of the proteins resident in this organelle and understanding how they integrate into pathways represent major challenges in cell biology. Toward this goal, we performed mass spectrometry, GFP tagging, and machine learning to create a mitochondrial compendium of 1098 genes and their protein...
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