Back to search

Article

A Molecular Mechanism for Turning off IRE1α Signaling During Endoplasmic Reticulum Stress

2020-04-04

Abstract excerpt

<h4>Summary</h4> Misfolded proteins in the endoplasmic reticulum (ER) activate IRE1α endoribonuclease in mammalian cells, which mediates XBP1 mRNA splicing to produce an active transcription factor. This promotes the expression of specific genes to alleviate ER stress and thereby attenuating IRE1α. Although sustained activation of IRE1α is linked to human diseases, it is not clear how IRE1α is attenuated during E...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
c9c27246-652f-5115-89b2-e3f91f95a8bf
DOI
10.1101/2020.04.03.024356
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A Molecular Mechanism for Turning off IRE1α Signaling During Endoplasmic Reticulum StressDOI 10.1101/2020.04.03.024356
A Molecular Mechanism for Turning Off IRE1α Signaling during Endoplasmic Reticulum StressSemantic proximity
Protein transport into the endoplasmic reticulum: mechanisms and pathologies.Semantic proximity
Sec63 and Xbp1 regulate IRE1α activity and polycystic disease severitySemantic proximity
Role of the HSP70 Co-Chaperone SIL1 in Health and Disease.Semantic proximity
SARS-CoV-2 diverges from other betacoronaviruses in only partially activating the IRE1α/XBP1 ER stress pathway in human lung-derived cellsSemantic proximity
IRE1 and efferent signaling from the endoplasmic reticulumSemantic proximity
ERdj3 regulates BiP occupancy in living cells.Semantic proximity
Stress-induced translocation of the endoplasmic reticulum chaperone GRP78/BiP and its impact on human disease and therapySemantic proximity
How IRE1 Reacts to ER StressSemantic proximity
ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stress.Semantic proximity
Noncanonical mRNA decay by the endoplasmic-reticulum stress sensor IRE1α promotes cancer-cell survivalSemantic proximity
Analysis of the XBP1 splicing mechanism using endoplasmic reticulum stress-indicatorsSemantic proximity
Select a neighboring publication to make it the new centre.