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Article

Protein transport into the endoplasmic reticulum: mechanisms and pathologies.

Trends in molecular medicine - 1 Dec 2006

Zimmermann Richard, Müller Linda, Wullich Bernd

Abstract excerpt

Transport into the endoplasmic reticulum (ER) is the crucial step in the biosynthesis of most secretory proteins and many membrane proteins. The products of the SIL1, SEC62 and SEC63 genes act in concert with the SEC61 complex and the molecular chaperones BiP and GRP170 to transport proteins into the ER. Interestingly, recent genetic work has linked mutations in the human and murine SIL1 genes to...

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Source

Identifiers

PMID: 17071140
DOI: 10.1016/j.molmed.2006.10.004

Genes

SEC63
SEC62
SIL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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