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Article

A Molecular Mechanism for Turning Off IRE1α Signaling during Endoplasmic Reticulum Stress

1 Dec 2020

Abstract excerpt

Misfolded proteins in the endoplasmic reticulum (ER) activate IRE1α endoribonuclease in mammalian cells, which mediates XBP1 mRNA splicing to produce an active transcription factor. This promotes the expression of specific genes to alleviate ER stress, thereby attenuating IRE1α. Although sustained activation of IRE1α is linked to human diseases, it is not clear how IRE1α is attenuated during ER stress. Here, we...

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PMID: 33378667
DOI: 10.1016/j.celrep.2020.108563

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