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The RIT2 and STX1B polymorphisms are associated with Parkinson's disease.

Parkinsonism & related disorders - 1 Mar 2015

Wang Jian-Yong, Gong Mei-Ying, Ye Yang-Lie, Ye Jin-Min, Lin Guo-Liang, Zhuang Qing-Qing, Zhang Xiong, Zhu Jian-Hong

Abstract excerpt

INTRODUCTION: GWAS meta-analysis identified RIT2 rs12456492 and STX1B rs4889603 as PD susceptible loci. While proteins encoded by the genes, in particular RIT2, may involve in PD pathogenesis, the association of these two variants with PD remains to be further clarified. METHODS: We enrolled a Chinese cohort comprising 537 PD patients and 517 controls, determined the genotypes of rs12456492 and rs4889603, and...

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Source

Identifiers

PMID: 25534083
DOI: 10.1016/j.parkreldis.2014.12.006

Genes

RIT2

Provenance

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