Article

Intra-Amniotic Transplantation of Brain-Derived Neurotrophic Factor - Modified Mesenchymal Stem Cells Treatment for Rat Fetuses with Spina Bifida Aperta

2022-03-08

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>Spina bifida aperta (SBA) is a relatively common clinical type of neural tube defect. Although prenatal fetal surgery has been proven to be an effective treatment for SBA, the recovery of neurological function remains unsatisfactory due to neuron deficiencies. Our previous results demonstrated that intra-amniotic transplanted bone marrow mesenchymal stem cells (BM...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c9a77c11-40bd-500b-9200-ed0604109a31
DOI: 10.21203/rs.3.rs-1271007/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Intra-Amniotic Transplantation of Brain-Derived Neurotrophic Factor - Modified Mesenchymal Stem Cells Treatment for Rat Fetuses with Spina Bifida ApertaDOI 10.21203/rs.3.rs-1271007/v1Read

Therapeutic potential of <i>in utero</i> mesenchymal stem cell (MSCs) transplantation in rat foetuses with spina bifida apertaSemantic proximity Read

Retinoic acid downregulates microRNAs to induce abnormal development of spinal cord in spina bifida rat modelSemantic proximity Read

Prenatal Transplantation of Human Amniotic Fluid Stem Cell Could Improve Clinical Outcome of Type III Spinal Muscular AtrophySemantic proximity Read

The Amniotic Fluid As a Source of Neural Stem Cells in the Setting of Experimental Neural Tube DefectsSemantic proximity Read

Disturbed apoptosis and cell proliferation in developing neuroepithelium of lumbo‐sacral neural tubes in retinoic acid‐induced spina bifida aperta in ratSemantic proximity Read

Human mesenchymal amniotic fluid stem cells reveal an unexpected neuronal potential differentiating into functional spinal motor neuronsSemantic proximity Read

Spina Bifida: Pathogenesis, Mechanisms, and Genes in Mice and HumansSemantic proximity Read

Spinal Cord Organoids from Human Amniotic Fluid iPSC Recapitulate the Diversity of Cell Phenotypes During Fetal Neural Tube MorphogenesisSemantic proximity Read

Folic Acid Exposure Rescues Spina Bifida Aperta Phenotypes in Human Induced Pluripotent Stem Cell Model.Semantic proximity Read

Human Transgene-Free Amniotic-Fluid-Derived Induced Pluripotent Stem Cells for Autologous Cell TherapySemantic proximity Read

Validation of the Fetal Lamb Model of Spina Bifida.Semantic proximity Read

HiPSC-Derived NSCs Effectively Promote The Functional Recovery of Acute Spinal Cord Injury in MiceSemantic proximity Read