Article
Validation of the Fetal Lamb Model of Spina Bifida.
Scientific reports - 27 Jun 2019
Joyeux Luc, Engels Alexander C, Van Der Merwe Johannes, Aertsen Michael, Patel Premal A, Deprez Marjolijn, Khatoun Ahmad, Pranpanus Savitree, da Cunha Marina Gabriela Monteiro Carvalho Mori, De Vleeschauwer Stephanie, Parra Johanna, Apelt Katerina, Laughlin Myles Mc, Van Calenbergh Frank, Radaelli Enrico, Deprest Jan
Abstract excerpt
A randomized trial demonstrated that fetal spina bifida (SB) repair is safe and effective yet invasive. New less invasive techniques are proposed but are not supported by adequate experimental studies. A validated animal model is needed to bridge the translational gap to the clinic and should mimic the human condition. Introducing a standardized method, we comprehensively and reliably characterize the SB...
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