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Spinal Cord Organoids from Human Amniotic Fluid iPSC Recapitulate the Diversity of Cell Phenotypes During Fetal Neural Tube Morphogenesis.

Molecular neurobiology - 1 Aug 2025

Biancotti Juan C, Moore Hannah E, Sescleifer Anne M, Sferra Shelby R, Penikis Annalise B, Miller Jena L, Kunisaki Shaun M

Abstract excerpt

Myelomeningocele (MMC) is a severe form of spina bifida associated with substantial neurologic morbidity. In vitro modeling systems of human spinal cord development may help to elucidate the underlying pathophysiology of the MMC spinal cord. To that end, we developed spinal cord organoids (SCO), defined as self-organized, three-dimensional clusters of spinal tissue, that were derived from human amniotic...

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PMID: 40254702
DOI: 10.1007/s12035-025-04944-z

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