Article
Folic Acid Exposure Rescues Spina Bifida Aperta Phenotypes in Human Induced Pluripotent Stem Cell Model.
Scientific reports - 13 Feb 2018
Sahakyan Vardine, Duelen Robin, Tam Wai Long, Roberts Scott J, Grosemans Hanne, Berckmans Pieter, Ceccarelli Gabriele, Pelizzo Gloria, Broccoli Vania, Deprest Jan, Luyten Frank P, Verfaillie Catherine M, Sampaolesi Maurilio
Abstract excerpt
Neural tube defects (NTDs) are severe congenital abnormalities, caused by failed closure of neural tube during early embryonic development. Periconceptional folic acid (FA) supplementation greatly reduces the risk of NTDs. However, the molecular mechanisms behind NTDs and the preventive role of FA remain unclear. Here, we use human induced pluripotent stem cells (iPSCs) derived from fetuses with spina bifida...
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