Article

IL-7 promotes CD19-directed CAR-T cells proliferation through miRNA-98-5p by targeting CDKN1A

2023-03-06

Abstract excerpt

CAR-T targeting CD19 have achieved significant effects in the treatment of B-line leukemia and lymphoma. However, the treated patients frequently relapsed and could not achieve complete remission. Therefore, improving the proliferation and cytotoxicity of CAR-T cells, reducing exhaustion and enhancing infiltration capacity are still issues to be solved. The IL-7 has been shown to enhance the memory characteristics...

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Literature Corpus work: c9a4dd6c-741d-515c-8b32-1b4be6e1e444
DOI: 10.21203/rs.3.rs-2614661/v1

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