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Article

Nonactivated and IL-7 cultured CD19-specific CAR T cells are enriched in stem cell phenotypes and functionally superior.

Blood advances - 23 Jan 2024

Wang Siao-Yi, Scurti Gina M, Dalheim Annika V, Quinn Suzanne, Stiff Patrick J, Nishimura Michael I

Abstract excerpt

ABSTRACT: CD19-specific chimeric antigen receptor (CAR) T cells have demonstrated impressive responses in patients with relapsed and refractory B cell malignancies. However, many patients relapse or fail to respond to CD19 CAR T cells, demonstrating the need to improve its efficacy and durability. Current protocols for generating CAR T cells involve T cell activation through CD3 stimulation to facilitate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37967375
DOI: 10.1182/bloodadvances.2023010607
PMCID: PMC10788799

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