Article
Secretion of human soluble programmed cell death protein 1 by chimeric antigen receptor-modified T cells enhances anti-tumor efficacy.
Cytotherapy - 1 Dec 2020
Zhang Ang, Sun Yao, Wang Shenyu, Du Jie, Gao Xiangyun, Yuan Ye, Zhao Long, Yang Yang, Xu Lei, Lei Yangyang, Duan Lian, Xu Chen, Ma Lei, Wang Jinyu, Hu Guoliang, Chen Hu, Wang Quanjun, Hu Liangding, Zhang Bin
Abstract excerpt
BACKGROUND AIMS: Chimeric antigen receptor (CAR) T cells have achieved favorable responses in patients with hematologic malignancies, but the outcome has been far from satisfactory in the treatment of tumors with high expression of immunosuppressive molecules. To overcome this limitation, we modified CAR T cells to secrete types of human soluble programmed cell death protein 1 (PD-1) called sPD-1 CAR T cells....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.