Article

Nicotinamide mononucleotide enhances the efficacy and persistence of CD19 CAR-T cells via NAD + –Sirt1 axis

2022-04-19

Abstract excerpt

<title>Abstract</title> <p>Chimeric antigen receptor (CAR)-modified T cells targeting antigens expressed on tumor cells have exhibited significant antitumor effects on several types of hematological malignancies, including acute myeloid leukemia, lymphoma, B cell maturation antigen, and CD19-positive acute lymphoblastic leukemia. However, several drawbacks, particularly the poor persistence, limit the use of CAR-...

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Literature Corpus work: 300bcb79-303d-5c44-88d2-f69b4bbf5a2a
DOI: 10.21203/rs.3.rs-1483519/v1

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