Article

Association Study of the SLC1A2 (rs4354668), SLC6A9 (rs2486001) and SLC6A5 (rs2000959) Polymorphisms in Major Depressive Disorder

2021-09-22

Abstract excerpt

<h4>Background: </h4> In recent years, a growing body of evidence highlights a causal link between glutamate and depression. The membrane excitatory amino acid transporter 2 (EAAT2), encoded by SLC1A2 is responsible for the uptake and redistribution of most of the synaptic glutamate. Glycine, an inhibitory neurotransmitter, acts as an obligatory co-agonist of N-methyl-D-aspartate (NMDA) receptors and modulates exc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c99c39a6-df2d-5f04-8a5b-4b0994ae40ff
DOI: 10.21203/rs.3.rs-900559/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Association Study of the SLC1A2 (rs4354668), SLC6A9 (rs2486001) and SLC6A5 (rs2000959) Polymorphisms in Major Depressive DisorderDOI 10.21203/rs.3.rs-900559/v1Read

Association Study of the SLC1A2 (rs4354668), SLC6A9 (rs2486001), and SLC6A5 (rs2000959) Polymorphisms in Major Depressive DisorderSemantic proximity Read

Genetic polymorphism involved in major depressive disorder: a systemic review and meta-analysis.Semantic proximity Read

5HTTLPR Genetic Variant and Major Depressive Disorder: A Review.Semantic proximity Read

Identification of SLC25A37 as a major depressive disorder risk gene.Semantic proximity Read

Effects of a Polymorphism of the Neuronal Amino Acid Transporter SLC6A15 Gene on Structural Integrity of White Matter Tracts in Major Depressive Disorder.Semantic proximity Read

The association between polymorphism of norepinephrine transporter G1287A and major depressive disorder, antidepressant response: a meta-analysis.Semantic proximity Read

Significant association of GRM7 and GRM8 genes with schizophrenia and major depressive disorder in the Han Chinese population.Semantic proximity Read

The molecular interaction between the glutamatergic, noradrenergic, dopaminergic and serotoninergic systems informs a detailed genetic perspective on depressive phenotypes.Semantic proximity Read

Multi-locus genome-wide association analysis supports the role of glutamatergic synaptic transmission in the etiology of major depressive disorder.Semantic proximity Read

A genetic variant in miRNA binding site of glutamate receptor 4, metabotropic (GRM4) is associated with increased risk of major depressive disorder.Semantic proximity Read

Meta-analysis of association between the -1438A/G (rs6311) polymorphism of the serotonin 2A receptor gene and major depressive disorder.Semantic proximity Read

The neuronal transporter gene SLC6A15 confers risk to major depression.Semantic proximity Read