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Article

A genetic variant in miRNA binding site of glutamate receptor 4, metabotropic (GRM4) is associated with increased risk of major depressive disorder.

Journal of affective disorders - 15 Jan 2017

Dadkhah Tahereh, Rahimi-Aliabadi Simin, Jamshidi Javad, Ghaedi Hamid, Taghavi Shaghyegh, Shokraeian Parasto, Akhavan-Niaki Haleh, Tafakhori Abbas, Ohadi Mina, Darvish Hossein

Abstract excerpt

BACKGROUND: Glutamate receptor 4, metabotropic (GRM4) expression is increased in the brain of patients with depression. The poorly conserved miR-1202 is downregulated in depression and is negatively correlated with GRM4. A variation located at the 3' UTR of the GRM4 gene may influence the interaction between miR-1202 and GRM4. The aim of this study was to determine the possible association between GRM4 3' UTR...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

Share to Receptors, Metabotropic Glutamate

Source

Identifiers

PMID: 27792966
DOI: 10.1016/j.jad.2016.10.008

Genes

GRM4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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