Article
Multi-locus genome-wide association analysis supports the role of glutamatergic synaptic transmission in the etiology of major depressive disorder.
Translational psychiatry - 13 Nov 2012
Lee P H, Perlis R H, Jung J-Y, Byrne E M, Rueckert E, Siburian R, Haddad S, Mayerfeld C E, Heath A C, Pergadia M L, Madden P A F, Boomsma D I, Penninx B W, Sklar P, Martin N G, Wray N R, Purcell S M, Smoller J W
Abstract excerpt
Major depressive disorder (MDD) is a common psychiatric illness characterized by low mood and loss of interest in pleasurable activities. Despite years of effort, recent genome-wide association studies (GWAS) have identified few susceptibility variants or genes that are robustly associated with MDD. Standard single-SNP (single nucleotide polymorphism)-based GWAS analysis typically has limited power to deal with...
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