Article
Meta-analysis of association between the -1438A/G (rs6311) polymorphism of the serotonin 2A receptor gene and major depressive disorder.
Neurological research - 1 Jan 2013
Jin Chunhui, Xu Wenwei, Yuan Jianmin, Wang Guoqiang, Cheng Zaohuo
Abstract excerpt
OBJECTIVES: Major depressive disorder (MDD) is a severe psychiatric disorder with a lifetime prevalence of approximately 10-15%. Previous pharmacological studies suggested that the serotonin 2A receptor (5-HTR2A) was one of the major pharmacological therapeutic targets for MDD. Recently, genetic studies investigated the association between the polymorphism rs6311 of the 5-HTR2A gene and MDD. However, the results...
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