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Structure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH

1 Mar 2022

Abstract excerpt

Glycoprotein 2 (GP2) and uromodulin (UMOD) filaments protect against gastrointestinal and urinary tract infections by acting as decoys for bacterial fimbrial lectin FimH. By combining AlphaFold2 predictions with X-ray crystallography and cryo-EM, we show that these proteins contain a bipartite decoy module whose new fold presents the high-mannose glycan recognized by FimH. The structure rationalizes UMOD...

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PMID: 35273390
DOI: 10.1038/s41594-022-00729-3

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