Article

Loss of Activity-Induced Mitochondrial ATP Production Underlies the Synaptic Defects in a <i>Drosophila</i> model of ALS

2021-12-16

Abstract excerpt

Mutations in the gene encoding VAPB (vesicle-associated membrane protein B) cause a familial form of Amyotrophic Lateral Sclerosis (ALS). Expression of an ALS-related variant of vapb ( vapb P58S ) in Drosophila motor neurons results in morphological changes at the larval neuromuscular junction (NMJ) characterized by the appearance of fewer, but larger, presynaptic boutons. Although diminished microtubule stabi...

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Literature Corpus work: c9943392-12c6-56be-be19-8a0e810e90fd
DOI: 10.1101/2021.12.14.472444

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