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Article

Defects in Synapse Structure and Function Precede Motor Neuron Degeneration in<i>Drosophila</i>Models of FUS-Related ALS

11 Dec 2013

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease that leads invariably to fatal paralysis associated with motor neuron degeneration and muscular atrophy. One gene associated with ALS encodes the DNA/RNA-binding protein Fused in Sarcoma (FUS). There now exist two Drosophila models of ALS. In one, human FUS with ALS-causing mutations is expressed in fly motor neurons; in the other,...

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Identifiers

PMID: 24336723
DOI: 10.1523/jneurosci.3396-13.2013

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Related research

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Defects in Synapse Structure and Function Precede Motor Neuron Degeneration in<i>Drosophila</i>Models of FUS-Related ALSPMID 24336723Read ↗

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Motor neuron apoptosis and neuromuscular junction perturbation are prominent features in a Drosophila model of Fus-mediated ALSSemantic proximity Read ↗

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Mitochondrial abnormalities and disruption of the neuromuscular junction precede the clinical phenotype and motor neuron loss in hFUSWT transgenic miceSemantic proximity Read ↗

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