Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Caffeine Has Different Immunomodulatory Effect on the Cytokine Expression and NLRP3 Inflammasome Function in Various Human Macrophage Subpopulations.

Nutrients - 14 Jul 2021

Kovács Elek Gergő, Alatshan Ahmad, Budai Marietta Margit, Czimmerer Zsolt, Bíró Eduárd, Benkő Szilvia

Abstract excerpt

Besides its well-known psychoactive effects, caffeine has a broad range of actions. It regulates several physiological mechanisms as well as modulates both native and adaptive immune responses by various ways. Although caffeine is assumed to be a negative regulator of inflammation, the effect on the secretion of pro- and anti-inflammatory cytokines is highly controversial. Macrophages are major mediators of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to AMP-Activated Protein Kinases
Share to Caffeine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunologic Factors

Share to Inflammasomes

Share to Macrophage Activation

Share to NLR Family, Pyrin Domain-Containing 3 Protein

Share to Receptor, Adenosine A2A

Share to STAT1 Transcription Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 34371919
DOI: 10.3390/nu13072409
PMCID: PMC8308523

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Caffeine Has Different Immunomodulatory Effect on the Cytokine Expression and NLRP3 Inflammasome Function in Various Human Macrophage Subpopulations.PMID 34371919Read ↗

Caffeine downregulates inflammatory pathways involved in autoimmunitySemantic proximity Read ↗

Kechuangping Mixture Inhibits LPS‑induced Macrophage Immune Response Through Suppressing the TLR4/MyD88/NF-κB Signal PathwaySemantic proximity Read ↗

Luteolin modulates macrophage phenotypic switching via the AMPK-PPARγ pathway to alleviate ulcerative colitis in mice.Semantic proximity Read ↗

Xanthoplanine attenuates macrophage polarization towards M1 and inflammation response via disruption of CrkL-STAT5 complex.Semantic proximity Read ↗

The Bitter the Taste, The Better is the Medicine: Is Caffeine the Answer to COVID-19?Semantic proximity Read ↗

Berberine alleviates DSS-induced colitis by modulating macrophage phenotype via PPAR-γ/ mTOR/HIF-1α signaling pathway.Semantic proximity Read ↗

<i>Kabasura Kudineer Choornam</i> , a medicinal polyherbal formulation, modulates human macrophage polarization and phagocytic functionSemantic proximity Read ↗

Cyclic AMP Regulates Key Features of Macrophages via PKA: Recruitment, Reprogramming and Efferocytosis.Semantic proximity Read ↗

Adenosine receptor activation promotes macrophage class switching from LPS-induced acute inflammatory M1 to anti-inflammatory M2 phenotype.Semantic proximity Read ↗

Primary Human M2 Macrophage Subtypes Are Distinguishable by Aqueous Metabolite Profiles.Semantic proximity Read ↗

Emerging Roles for G-protein Coupled Receptors in Development and Activation of MacrophagesSemantic proximity Read ↗

Modulation of IRAK4 as a Therapeutic Strategy Against Monosodium Urate- and Xanthine-Induced Inflammation in Macrophages and HepG2 CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.