Article
Control of inducible gene expression links cohesin to hematopoietic progenitor self-renewal and differentiation.
Nature immunology - 1 Sept 2018
Cuartero Sergi, Weiss Felix D, Dharmalingam Gopuraja, Guo Ya, Ing-Simmons Elizabeth, Masella Silvia, Robles-Rebollo Irene, Xiao Xiaolin, Wang Yi-Fang, Barozzi Iros, Djeghloul Dounia, Amano Mariane T, Niskanen Henri, Petretto Enrico, Dowell Robin D, Tachibana Kikuë, Kaikkonen Minna U, Nasmyth Kim A, Lenhard Boris, Natoli Gioacchino, Fisher Amanda G, Merkenschlager Matthias
Abstract excerpt
Cohesin is important for 3D genome organization. Nevertheless, even the complete removal of cohesin has surprisingly little impact on steady-state gene transcription and enhancer activity. Here we show that cohesin is required for the core transcriptional response of primary macrophages to microbial signals, and for inducible enhancer activity that underpins inflammatory gene expression. Consistent with a role...
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