Article
Homologous recombination generates T-loop-sized deletions at human telomeres.
Cell - 29 Oct 2004
Wang Richard C, Smogorzewska Agata, de Lange Titia
Abstract excerpt
The t-loop structure of mammalian telomeres is thought to repress nonhomologous end joining (NHEJ) at natural chromosome ends. Telomere NHEJ occurs upon loss of TRF2, a telomeric protein implicated in t-loop formation. Here we describe a mutant allele of TRF2, TRF2DeltaB, that suppressed NHEJ but induced catastrophic deletions of telomeric DNA. The deletion events were stochastic and occurred rapidly, generating...
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