Article

Analysis of single-cell RNA-sequencing data to identify quiescent and proliferating neural cell populations in Glioblastoma

2021-12-10

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Diffuse Glioblastoma (GBM) has high mortality and remains one of the most challenging type of cancer to treat. Identifying and characterizing the cells populations driving tumor growth and therapy resistance has been particularly difficult owing to marked inter and intra tumoral heterogeneity observed in these tumors. These tumorigenic populations contain long lived cells as...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2405c2c1-c908-5aac-bfdc-7efbaa5be853
DOI: 10.1101/2021.12.09.472030

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Analysis of single-cell RNA-sequencing data to identify quiescent and proliferating neural cell populations in GlioblastomaDOI 10.1101/2021.12.09.472030Read

Single-cell RNA-seq reveals that glioblastoma recapitulates normal brain developmentSemantic proximity Read

Neural G0: a quiescent-like state found in neuroepithelial-derived cells and gliomaSemantic proximity Read

Shared molecular regulation of quiescence in neural and glioma stem cells reveals therapeutic vulnerabilitiesSemantic proximity Read

Gene signatures of quiescent glioblastoma cells reveal mesenchymal shift and interactions with niche microenvironmentSemantic proximity Read

Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma.Semantic proximity Read

Adult Human Glioblastomas Harbor Radial Glia-like CellsSemantic proximity Read

Quiescent stem cell marker genes in glioma gene networks are sufficient to distinguish between normal and glioblastoma (GBM) samples.Semantic proximity Read

Dissecting human gliomas by single-cell RNA sequencingSemantic proximity Read

Characterization of quiescent subpopulations and proliferative compartments in glioblastomaSemantic proximity Read

Classifying cell cycle states and a quiescent-like G0 state using single-cell transcriptomicsSemantic proximity Read

Identification of glioblastoma stem cell-associated lncRNAs using single-cell RNA-sequencing datasetsSemantic proximity Read

Single-Cell RNA-Seq Analysis of Infiltrating Neoplastic Cells at the Migrating Front of Human GlioblastomaSemantic proximity Read