Article

FABP4 Couples Lipid Metabolism to PD-L1 Stabilization in Immunosuppressive Macrophages

2026-04-13

Abstract excerpt

<h4>Summary</h4> Metabolic dysregulation in obesity reshapes immune function, but how lipid signals drive immune suppression remains unclear. Here, we identify a FABP4–PD-L1 axis that links lipid metabolism to immune checkpoint regulation in monocytes and macrophages. Single-cell transcriptomics revealed a distinct FABP4 high immunosuppressive macrophage subset enriched under high-fat diet (HFD) conditions, char...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 35ab070f-0acb-5646-b612-94283f56637e
DOI: 10.64898/2026.04.09.717546

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

FABP4 Couples Lipid Metabolism to PD-L1 Stabilization in Immunosuppressive MacrophagesDOI 10.64898/2026.04.09.717546Read

Fatty Acids Support the Fitness and Functionality of Tumor-Resident CD8+ T Cells by Maintaining SCML4 ExpressionSemantic proximity Read

Macrophage Plasticity: Phenotypic and Functional Profiles Across Pathological Microenvironments.Semantic proximity Read

Identification of conserved and tissue-restricted transcriptional profiles for lipid associated macrophages (LAMs)Semantic proximity Read

Lipogenesis-driven EGFR palmitoylation enables metastatic immune evasion in triple-negative breast cancerSemantic proximity Read

Integrative Analysis of Lipid Metabolism-Associated Genes Unveils ALDH2 as a Prognostic Marker in Breast CancerSemantic proximity Read

BET proteins in abnormal metabolism, inflammation, and the breast cancer microenvironmentSemantic proximity Read

Insulin regulates lymphatic endothelial function via palmitoylationSemantic proximity Read

Delineation of signaling routes that underlie differences in macrophage phenotypic statesSemantic proximity Read

Diagnostic, Prognostic, and Immunological Roles of FABP4 in Pancancer: A Bioinformatics AnalysisSemantic proximity Read

Tumour cell-expressed PD-L1 reprograms lipid metabolism via EGFR/ITGB4/SREBP1c signalling in liver cancerSemantic proximity Read

Single-Cell and Single-Nuclei transcriptomics profiling reveals dynamic cellular features in tumor-related adipose microenvironment of breast cancer patients with high BMISemantic proximity Read

A Fatty Acid Metabolic Signature for Prognosis (FAMOUS) in Breast CancerSemantic proximity Read