Article

Quantification of Subtype Purity in Luminal A Breast Cancer Predicts Clinical Characteristics and Survival

2023-03-01

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Purpose</h4> PAM50 profiling assigns each breast cancer to a single intrinsic subtype based on a bulk tissue sample. However, individual cancers may show evidence of admixture with an alternate subtype that could affect prognosis and treatment response. We developed a method to model subtype admixture using semi-supervised non-negative matrix factorization (ssNMF) of whole transcriptome data...

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Literature Corpus work: c94e0ef9-92d0-528a-baf1-af4b81b2fce7
DOI: 10.1101/2023.02.27.23286511

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